Production of lysergic acid by genetic modification of a fungus

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United States of America Patent

PATENT NO 9790528
SERIAL NO

14739382

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Abstract

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The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus, is provided.

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Patent Owner(s)

Patent OwnerAddress
WEST VIRGINIA UNIVERSITYCHESTNUT RIDGE RESEARCH BLDG 886 CHESTNUT RIDGE ROAD P O BOX 6224 MORGANTOWN VA 26506-6216

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Panaccione, Daniel G Morgantown, US 2 2
Robinson, Sarah L Independence, US 2 2

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