Designer cells for enantioselective reduction of ketones and use thereof in efficient production of enantioenriched alcohols
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United States of America Patent
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Oct 17, 2017
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Apr 17, 2014
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Apr 17, 2013
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Abstract
The present invention is to provide a preparation of variant recombinant whole cell biocatalysts, referred herein as “designer cells” having significantly enhanced carbonyl reductase activity for use in the efficient production of variant industrially important enantiomerically enriched alcohols. More specifically, the alcohol is optically pure ethyl (S)-4-chloro-3-hydroxybutyrate, which is useful as chiral building block and an intermediate for the production of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors.
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