Functionally-modified oligonucleotides and subunits thereof
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United States of America Patent
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Oct 17, 2017
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app pub date -
Jan 26, 2016
filing date -
Nov 18, 2011
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Abstract
Functionally-modified oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
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