Neural cell populations from primate pluripotent stem cells

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United States of America Patent

PATENT NO 9790466
SERIAL NO

13561296

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly onto a differentiation-promoting surface, or grown initially on the solid surface in the absence of feeder cells and then exchanged into a medium that assists in the differentiation process. The solid surface and the culture medium can be chosen to direct differentiation down a particular pathway, generating a cell population that is remarkably uniform. The methodology is well adapted to bulk production of committed precursor and terminally differentiated cells for use in drug screening or regenerative medicine.

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Patent Owner(s)

Patent OwnerAddress
ASTERIAS BIOTHERAPEUTICS INC2173 SALK AVENUE SUITE 200 CARLSBAD CA 92008

International Classification(s)

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  • 2012 Application Filing Year
  • C12R Class
  • 82 Applications Filed
  • 73 Patents Issued To-Date
  • 89.03 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20122013201420152016201720182019202020210255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carpenter, Melissa K Castro Valley, US 40 1328
Thies, R Scott Pleasanton, US 30 587

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Patent Citation Ranking

  • 2 Citation Count
  • C12R Class
  • 0 % this patent is cited more than
  • 8 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges11 - 1000.050.10.150.20.250.30.350.40.450.50.550.60.650.70.750.80.850.90.9511.05

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