Arginine deiminase with reduced cross-reactivity toward ADI-PEG 20 antibodies for cancer treatment
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United States of America Patent
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Oct 17, 2017
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Sep 16, 2015
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Sep 16, 2014
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Abstract
The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.
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