Compounds as HIF-1α inhibitors and manufacturing process thereof
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United States of America Patent
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Oct 17, 2017
Grant Date -
Jul 7, 2016
app pub date -
Mar 10, 2016
filing date -
Sep 27, 2011
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Abstract
The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.
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