Compositions and methods for dengue virus chimeric constructs in vaccines

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United States of America Patent

PATENT NO 9783579
SERIAL NO

14209808

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Abstract

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Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.

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Patent Owner(s)

  • TAKEDA VACCINES, INC.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinney, Claire Fort Collins, US 8 4
Kinney, Richard M Fort Collins, US 13 154
Livengood, Jill A Fort Collins, US 27 32
Stinchcomb, Dan T Fort Collins, US 66 780

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