Process for the manufacture of isavuconazole or ravuconazole

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United States of America Patent

PATENT NO 9783508
SERIAL NO

14419153

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Abstract

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The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.

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Patent Owner(s)

Patent OwnerAddress
BASILEA PHARMACEUTICA AG4058 BASEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mink, Daniel Eupen, BE 17 130
Vaessen, Harrie Wijnandsrade, NL 2 3
Van, Summeren Ruben Weert, NL 3 3
Waser, Mario Leonding, AT 3 3

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