Anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing culture medium of ADSC-T cells in which T-antigen is introduced into adipose-derived stem cell as active ingredient
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United States of America Patent
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Oct 10, 2017
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Aug 29, 2013
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Apr 19, 2013
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Abstract
The present invention relates to an anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing a culture medium of adipose-derived stem cell-T (ADSC-T) cells as an active ingredient, in which T-antigen is introduced into an adipose-derived stem cell. The culture medium of ADSC-T cells, according to the present invention, has remarkable effects for treating or inhibiting inflammation by alleviating atopic dermatitis, which is an autoimmune disease, and inhibiting NF-κB activities through an increase of an Iκbα expression. Additionally, the culture medium, according to the present invention, exhibits: excellent skin regenerative effects by having effects of enhancing skin collagen elasticity and reducing wounds, in a collagen culture; excellent skin whitening effects by inhibiting tyrosinase activities and melanin production; and excellent anti-oxidation effects by inhibiting DPPH radical activities. Furthermore, the present invention has remarkable wound-healing effects by enhancing cell mobility of fibroblast, and is thus useful for anti-inflammation, skin-regeneration, whitening, anti-oxidation, or healing wounds.
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