Mito-Ob: a transgenic mouse model for obesity

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United States of America Patent

PATENT NO 9781909
SERIAL NO

14328888

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Abstract

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An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MANITOBAROOM 202 ADMINISTRATION BUILDING WINNIPEG R3T 2N2

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ande, Sudharsana R Winnipeg, CA 1 10
Mishra, Suresh Winnipeg, CA 3 10

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