Molecular adaptors for dye conjugates

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United States of America Patent

PATENT NO 9777320
SERIAL NO

13218439

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Abstract

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In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

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PACIFIC BIOSCIENCES OF CALIFORNIA INC1305 O'BRIEN DRIVE MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brogley, Louis Santa Cruz, US 31 589
Sebo, Lubomir Redwood City, US 39 810
Shen, Gene Santa Clara, US 61 1523
Wegener, Jeffrey Cupertino, US 26 2014
Yue, Stephen Eugene, US 116 1576

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