Methods for the treatment of Leber congenital amaurosis

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United States of America Patent

PATENT NO 9777272
SERIAL NO

15267175

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Abstract

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The present invention relates to a method for treating a Leber congenital amaurosis in a patient harboring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2291+1655 A>G CEP290 mRNA.

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UNIVERSITÉ PARIS CITÉ85 BOULEVARD SAINT-GERMAIN PARIS 75006

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gerard, Xavier Paris, FR 8 23
Kaplan, Josseline Paris, FR 12 24
Kichler, Antoine Evry, FR 9 29
Munnich, M Arnold Paris, FR 5 18
Perrault, Isabelle Paris, FR 11 24
Rozet, Jean-Michel Paris, FR 13 24
Scherman, Daniel Paris, FR 50 543

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