Construction and application of bispecific antibody EpCAM×CD3
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United States of America Patent
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Oct 3, 2017
Grant Date -
Mar 31, 2016
app pub date -
Jul 20, 2015
filing date -
Jul 21, 2014
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Abstract
The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against the surface antigen EpCAM of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
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