Chelate nanoemulsion for MRI

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United States of America Patent

PATENT NO 9770520
SERIAL NO

13995732

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Abstract

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The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising:

    an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82%a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%,a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid;the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%;the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.5% and 2%;the oil comprising at least 70%, advantageously at least 80%, advantageously at least 95% by weight and especially at least 97% of saturated C6-C18, advantageously C6-C14 and more advantageously C6-C10 fatty acids.

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Patent Owner(s)

Patent OwnerAddress
GUERBET15 RUE DES VANESSES VILLEPINTE 93420
UNIVERSITE DE BORDEAUX 1351 COURS DE LA LIBERATION TALENCE CEDEX F-33402

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chadel, Samy Genas, FR 1 25
Leal, Calderon Fernando La Brede, FR 6 104
Port, Marc Deuil la Barre, FR 33 226
Robic, Caroline Nogent sur Marne, FR 10 29

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