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United States of America Patent

PATENT NO 9770495
SERIAL NO

14824957

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Abstract

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The present invention provides the in-vitro use of at least one in-vivo-target antigen of Aspergillus fumigatus for selective activation, detection and/or analysis of Aspergillus fumigatus specific CD4+ T cells in a sample comprising cells, wherein said at least one in-vivo-target antigen reveals an immune reactivity characterized by i) the in vivo existence of antigen-specific T cells comprising more than 60% memory T cells and ii) said antigen-specific T cells further comprise T cells able to produce IFN-gamma upon stimulation at a frequency between 15% and 80% and/or IL17 upon stimulation at a frequency between 5% and 30%. Said at least one in-vivo-target antigen may be selected from the group consisting of antigens Scw4, Pst1, Shm2, GliT and TpiA or fragments thereof. Also provided are a method, a composition, and a kit thereof.

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Patent Owner(s)

Patent OwnerAddress
LEIBNIZ INSTITUTE FOR NATURAL PRODUCT RESEARCH AND INFECTION BIOLOGYADOLF-REICHWEIN-STRASSE 23 HANS KNOLL INSTITUTE JENA 07745

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bacher, Petra Berlin, DE 2 2
Brakhage, Axel Weimar, DE 4 7
Kniemeyer, Olaf Jena, DE 1 1
Scheffold, Alexander Berlin, DE 15 50
Teutschbein, Janka Jena, DE 1 1

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