Method for producing a polyglycerol nanogel for the encapsulation and release of biologically active substances

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United States of America Patent

PATENT NO 9770420
APP PUB NO 20150283094A1
SERIAL NO

14426713

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Abstract

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A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.

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Patent Owner(s)

Patent OwnerAddress
FREIE UNIVERSITAT BERLIN14195 BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Friess, Wolfgang Iffeldorf, DE 20 362
Haag, Rainer Berlin, DE 34 103
Küchler, Sarah München, DE 1 0
Steinhilber, Dirk Berlin, DE 4 0
Witting, Madeleine München, DE 1 0

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