Antibody polypeptides that antagonize CD40L

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United States of America Patent

PATENT NO 9765150
SERIAL NO

14950949

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Abstract

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Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

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Patent Owner(s)

Patent OwnerAddress
BRISTOL-MYERS SQUIBB COMPANY345 PARK AVENUE NEW YORK N Y 10154

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bryson, James William Langhorne, US 7 54
Drew, Philip Histon, GB 10 93
Grant, Steven Swaffham Prior, GB 45 372
Ignatovich, Olga Cambridge, GB 41 429
Nadler, Steven G Princeton, US 39 175
Price, Laura Langhorne, US 11 96
Rehfuss, Robert P North Wales, US 11 77
Suchard, Suzanne J Wilmington, US 24 130
Suri, Anish Yardley, US 29 126
Tamura, James K Yardley, US 10 54
Yamniuk, Aaron Lawrenceville, US 22 118

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