2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
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United States of America Patent
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Sep 19, 2017
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Sep 11, 2014
filing date -
Jan 21, 2000
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Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
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