Small-molecule-targeted protein degradation
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United States of America Patent
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Sep 19, 2017
Grant Date -
Jul 25, 2013
app pub date -
Jun 30, 2011
filing date -
Jun 30, 2010
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Abstract
Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
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