Homologous recombination in multipotent adult progenitor cells

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United States of America Patent

PATENT NO 9764044
APP PUB NO 20100285590A1
SERIAL NO

12784579

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Abstract

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The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.

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Patent Owner(s)

Patent OwnerAddress
ABT HOLDING COMPANYCLEVELAND OH 44115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lakshmipathy, Uma Carlsbad, US 12 100
Verfaillie, Catherine Leuven, BE 10 83

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