Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof
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United States of America Patent
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Sep 19, 2017
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Mar 9, 2017
app pub date -
Jun 16, 2016
filing date -
Aug 10, 2009
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Abstract
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
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