Bioluminescence resonance energy transfer between bioluminescent proteins and semiconductive nanomaterials

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United States of America Patent

PATENT NO 9758808
SERIAL NO

14073463

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A bioluminescence energy transfer (BRET) nanosystem having semiconductive quantum rods (QRs) bound by firefly luciferase Photinus pyralis (Ppy) for improved conversion of chemical energy to light, such as in solid-state lighting, near-infrared imaging systems, and in vivo infrared imaging. The nanosystems are formed by synthesizing CdSe/CdS or CdSe/CdS/ZnS quantum rods, rendering the dots hydrophilic and colloidially stable with a facile His-capping, incubating with a Ppy variant (PpyGRTS) at increasing loading ratios, and adding an excess of the luciferin (LH2) substrate to the PpyGRTS-QRs.

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SYRACUSE UNIVERSITY304 LYMAN HALL SYRACUSE NY 13224

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alam, Rabeka Syracuse, US 1 1
Maye, Mathew Binghamton, US 7 13

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