Iron oxide nanocapsules, method of manufacturing the same, and MRI contrast agent using the same

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United States of America Patent

PATENT NO 9757482
SERIAL NO

13819525

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Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided.

description='In-line Formulae' end='lead'5≦100*Dμ(IO)/Cω(IO)  [Relation 1]description='In-line Formulae' end='tail'

description='In-line Formulae' end='lead'2.5≦100*Dμ(Cap)/Cω(Cap)  [Relation 2]description='In-line Formulae' end='tail'

description='In-line Formulae' end='lead'0.5 wt %≦F(IO)≦50 wt %  [Relation 3]description='In-line Formulae' end='tail'

description='In-line Formulae' end='lead'1 nm≦Dμ(IO)≦25 nm  [Relation 4]description='In-line Formulae' end='tail'

description='In-line Formulae' end='lead'50 nm≦Dμ(Cap)≦200 nm  [Relation 5]description='In-line Formulae' end='tail'

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HANWHA CHEMICAL CORPORATION86 CHEONGGYECHEON-RO JUNG-GU SEOUL 04541

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jeon, Bong-Sik Daejeon, KR 5 15
Kim, Eung Gyu Daejeon, KR 9 13
Kwon, Eun Byul Daejeon, KR 7 13
Myeong, Wan Jae Daejeon, KR 20 59
Park, Ju Young Daejeon, KR 71 175

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