Method for measuring cell-to-cell transmission of α-synuclein aggregates using bimolecular fluorescence complementation system and method for screening a substance for preventing or treating neurodegenerative disease using the same

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United States of America Patent

PATENT NO 9757402
SERIAL NO

14855645

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The present disclosure relates to dual-cell model and Caenorhabditis elegans model systems for measuring neuron-to-neuron transmission of protein aggregates, and more particularly to transgenic cell and animal model systems expressing fusion proteins of N-terminus or C-terminus of fluorescent proteins with α-synuclein proteins, methods for measuring continuous cell-to-cell transmission of α-synuclein aggregates using the same, and methods for screening substances for preventing or treating neurodegenerative diseases.

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Patent OwnerAddress
NEURAMEDY CO LTDRM408 CONVERGENCE RESEARCH CENTER COLLEGE OF MEDICINE SNU 103 DAEHAK-RO JONGNO-GU SEOUL 03080

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bae, Eun-Jin Seoul, KR 3 13
Kim, Dong Kyu Seoul, KR 101 1009
Lee, He-Jin Seoul, KR 1 1
Lee, Seung-Jae Seoul, KR 228 2335

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