Composition for treatment or metastasis suppression of cancers which includes p34 expression inhibitor or activity inhibitor as active ingredient

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United States of America Patent

PATENT NO 9752151
SERIAL NO

14779874

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Abstract

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The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION93 DAEHAK-RO NAM-GU ULSAN 680-749
THE ASAN FOUNDATION88 OLYMPIC-RO 43-GIL SONGPA-GU SEOUL 138-736

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Eun Kyung Seoul, KR 18 91
Hong, Seung Woo Seoul, KR 37 196
Hong, Yong Sang Seoul, KR 3 0
Jin, Dong Hoon Seoul, KR 8 1
Jung, Kyung Ah Seoul, KR 1 0
Kim, Bong Cheol Seoul, KR 17 194
Kim, Jin Sun Seoul, KR 31 126
Kim, Kyu Pyo Seoul, KR 2 0
Kim, Tae Won Seoul, KR 105 946
Lee, Jae Lyun Seoul, KR 2 0
Lee, Jung Shin Seoul, KR 6 0
Moon, Jai Hee Seoul, KR 8 0
Nam, Ky Youb Seoul, KR 9 5
Shin, Jae Sik Seoul, KR 20 0

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