Uridine diphosphate derivatives, prodrugs, compositions and methods for treating neurodegenerative disorders
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United States of America Patent
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Sep 5, 2017
Grant Date -
Aug 25, 2016
app pub date -
Oct 16, 2015
filing date -
Sep 28, 2012
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Abstract
This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions.
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