Method for identifying activation of transferases

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United States of America Patent

PATENT NO 9747412
SERIAL NO

13880447

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a method for identifying differential activation of a bisubstrate protein modifying enzyme between samples, comprising:

    (i) incubating a first sample with x different concentrations of the non-protein substrate of said enzyme, wherein x is 2 or greater than 2;(ii) quantifying modification of a polypeptide in said sample at each of the x different concentrations of the non-protein substrate;(iii) determining the affinity of said enzyme for said non-protein substrate;(iv) repeating steps (i) to (iii) for a second or subsequent sample; and(v) comparing the affinity of said enzyme for said non-protein substrate between said samples;wherein a difference in affinity of said enzyme for said non-protein substrate between samples is indicative of differential activation of said enzyme between samples. The present invention also provides a method for identifying an in vivo substrate of a bisubstrate protein modifying enzyme.

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Patent Owner(s)

  • HVIVO SERVICES LIMITED

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beltran, Luisa Marie Charterhouse Square, GB 1 0
Rodriguez, Cutillas Pedro Charterhouse Square, GB 4 1
Vanhaesebroeck, Bart Charterhouse Square, GB 9 127

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