In vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin

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United States of America Patent

PATENT NO 9745629
SERIAL NO

15196393

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Abstract

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The identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1 is provided. An in vitro method for screening for candidate compounds includes:

    (a) bringing at least one test compound in contact with a sample of keratinocytes in vitro;(b) measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in the keratinocytes; and(c) selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of the LARGE, HS6ST2 and ST8SIA1 genes is measured in the keratinocytes treated in (a) compared with the untreated keratinocytes.

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Patent Owner(s)

Patent OwnerAddress
CHANEL PARFUMS BEAUTE135 AVENUE CHARLES DE GAULLE 92200 NEUILLY-SUR-SEINE 92200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fedorova, Elena Whippany, US 7 1
Lasserre, Christelle Jersey City, US 7 20

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