Irreversible covalent inhibitors of the GTPase K-Ras G12C

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United States of America Patent

PATENT NO 9745319
APP PUB NO 20160031898A1
SERIAL NO

14777334

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Abstract

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Irreversible inhibitors of K-Ras, H-Ras or N-ras protein comprising a G12C mutation are provided. Also disclosed are methods to regulate the activity of K-Ras, H-Ras or N-ras protein comprising G12C mutation and methods to disease mediated by K-Ras, H-Ras or N-ras G12C.

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Patent Owner(s)

Patent OwnerAddress
ARAXES PHARMA LLC3033 SCIENCE PARK ROAD SUITE 220 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Feng, Jun San Diego, US 210 4080
Li, Liansheng San Diego, US 158 5429
Liu, Yi San Diego, US 838 10296
Ren, Pingda San Diego, US 198 6390

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