Genetically engineered bacterium comprising energy-generating fermentation pathway
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United States of America Patent
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Aug 22, 2017
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Apr 13, 2017
app pub date -
Oct 13, 2016
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Oct 13, 2015
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Abstract
The invention relates to a genetically engineered bacterium comprising an energy-generating fermentation pathway and methods related thereto. In particular, the invention provides a bacterium comprising a phosphate butyryltransferase (Ptb) and a butyrate kinase (Buk) (Ptb-Buk) that act on non-native substrates to produce a wide variety of products and intermediates. In certain embodiments, the invention relates to the introduction of Ptb-Buk into a C1-fixing microoorgansim capable of producing products from a gaseous substrate.
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