Method for selecting a single cell expressing a heterogeneous combination of antibodies

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United States of America Patent

PATENT NO 9738701
SERIAL NO

12931955

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Abstract

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The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.

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Patent Owner(s)

Patent OwnerAddress
MERUS N V3584 CT UTRECHT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hoogenboom, Hendricus Renerus Maastricht, NL 6 83
Logtenberg, Ton Utrecht, NL 96 2507

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