Processes for making hydrazides
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United States of America Patent
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Aug 22, 2017
Issued Date -
Jun 23, 2016
app pub date -
Dec 18, 2015
filing date -
May 22, 2007
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Abstract
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
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