Biochemical markers for neurodegenerative conditions
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United States of America Patent
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Aug 15, 2017
Grant Date -
Mar 5, 2015
app pub date -
Jul 4, 2012
filing date -
Jul 4, 2011
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Abstract
Provided herein is a method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions. The method comprises cleaving a Tau protein by a secretase, such as ADAM10, to form a neo-epitope. The method comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of the antibody to peptide fragments comprising the neo-epitope in the sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
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