Biomarker for determining mitochondrial damage in friedreich's ataxia
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United States of America Patent
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Aug 15, 2017
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app pub date -
Mar 1, 2013
filing date -
Mar 2, 2012
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Abstract
Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mitochondrial proteins. Also disclosed are methods of detecting progression of a disease or a disorder associated with a deficiency in frataxin in a subject and methods of monitoring effectiveness of a therapy for diseases or disorders associated with a deficiency in frataxin.
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