Functionalized titanium binding peptides and implants coated with same

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United States of America Patent

PATENT NO 9731048
SERIAL NO

14405192

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Abstract

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An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein:

    (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide;(ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and(ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions.

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Patent Owner(s)

Patent OwnerAddress
BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY84105 BEER SHEVA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gittelman, Anna Arad, IL 2 4
Rapaport, Hanna LeHavim, IL 9 28

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