5′-end derivatives

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United States of America Patent

PATENT NO 9725479
SERIAL NO

13696796

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Abstract

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The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 92010

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lima, Walter F San Diego, US 30 760
Manoharan, Muthiah Weston, US 491 18658
Prakash, Thazha P Carlsbad, US 184 5389
Rajeev, Kallanthottathil G Wayland, US 260 8660
Swayze, Eric E Encinitas, US 355 10308
Zlatev, Ivan Cambridge, US 29 408

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