Substituted indoles and pyrroles as RIP kinase inhibitors
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United States of America Patent
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Aug 8, 2017
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Mar 14, 2014
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Mar 15, 2013
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Abstract
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.
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