Quinazoline derivative and preparation method therefor

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United States of America Patent

PATENT NO 9725439
APP PUB NO 20160214964A1
SERIAL NO

15024472

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Abstract

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The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.

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Patent Owner(s)

  • CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.;LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Han, Yongxin Beijing, CN 117 658
Hu, Yuandong Beijing, CN 16 65
Kong, Fansheng Beijing, CN 8 34
Li, Jijun Beijing, CN 13 235
Luo, Hong Beijing, CN 71 630
Peng, Yong Beijing, CN 54 350
Wang, Huting Beijing, CN 8 23
Xiao, Dengming Beijing, CN 62 625
Zhang, Hui Beijing, CN 899 8264
Zhu, Yan Beijing, CN 239 1399

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