Nanospheres for therapeutic agent delivery

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United States of America Patent

PATENT NO 9724304
SERIAL NO

13918019

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Abstract

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Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or dispersed in the oil. In some embodiments, the nanosphere is pegylated. In some embodiments, the nanosphere has a diameter of from about 100 nm to about 300 nm. In further preferred embodiments, the nanosphere has a diameter of from about 150 nm to about 250 nm. In yet further embodiments, the nanosphere has a diameter of from about 180 nm to about 220 nm. In some embodiments, the oil comprises a lipid or a phospholipid. In further embodiments, the lipid or the phospholipid has a melting point below 20° C. In some embodiments, the polymer is a natural, modified or synthetic polymer. In further embodiments, the polymer is biodegradable.

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Patent Owner(s)

Patent OwnerAddress
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONBROAD STREET AND MONTGOMERY AVENUE PHILADELPHIA PA 19122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Narvekar, Mayuri Philadelphia, US 1 2
Wong, Ho Lun Elkins Park, US 3 2
Xue, Hui Yi Elkins Park, US 1 2

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