OX40L fusion proteins and uses thereof

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United States of America Patent

PATENT NO 9718870
SERIAL NO

14722679

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Abstract

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The disclosure provides OX40L huIgG4 fusion polypeptide subunits comprising a human IgG4 Fc domain, a trimerization domain, and the receptor binding domain of Ox40 ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.

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Patent Owner(s)

Patent OwnerAddress
MEDIMMUNE LLCONE MEDIMMUNE WAY GAITHERSBURG MD 20878

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Damschroder, Melissa Gaithersburg, US 44 763
Feng, Hui Potomac, US 66 186
Hammond, Scott Gaithersburg, US 41 1430
Oberst, Michael Gaithersburg, US 13 113

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