Use of aryl-quinolin derivatives as inhibitors of vasculogenic mimicry
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United States of America Patent
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Aug 1, 2017
Grant Date -
Dec 8, 2016
app pub date -
Jun 2, 2016
filing date -
Jun 3, 2015
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Abstract
Aryl-quinolin derivatives for use in inhibiting vasculogenic mimicry, treating diseases characterized by abnormal vascular morphology or function and/or by the presence of vasculogenic mimicry in a subject in need thereof are disclosed. In one embodiment of the invention, the compounds are for use in treating metastatic tumor, hyperproliferative, or angiogenic diseases. In another embodiment of the invention, the compound for use may combine an additional therapeutic agent such as anti-cancer agents, anti-inflammatory agents, anti-proliferative agents, anti-hormonal agents, or any combination thereof for use.
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