Weekly dosing regimens for anti-CD30 VC-PAB-MMAE antibody drug-conjugates
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United States of America Patent
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Jul 25, 2017
Grant Date -
May 12, 2016
app pub date -
Nov 11, 2015
filing date -
Jan 9, 2009
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Abstract
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.
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