Methods for making pharmaceutical solid dosage forms of spray-dried dispersions
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United States of America Patent
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Jul 25, 2017
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app pub date -
Sep 5, 2013
filing date -
Sep 11, 2012
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Abstract
An exemplary method comprises providing a spray-dried dispersion comprising particles, the particles comprising an active agent and a polymer, the dispersion particles having an average particle diameter of less than 50 μm. An ordered mixture is formed by high-shear mixing the dispersion with a powdered glidant, wherein the average particle diameter of the glidant is less than or equal to one fifth the average particle diameter of the dispersion after high-shear mixing. The dosage forms are formed by at least one of directly compressing the ordered mixture to form a tablet and encapsulating the ordered mixture to form a capsule.
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