Phosphorodiamidate backbone linkage for oligonucleotides
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United States of America Patent
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Jul 18, 2017
Grant Date -
Apr 23, 2015
app pub date -
Sep 26, 2014
filing date -
Sep 30, 2013
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Abstract
This invention relates to antisense oligonucleotides comprising at least one N3′→P5′ phosphorodiamidate linkage (NPN) in the backbone, and kits and pharmaceutical compositions thereof, useful for modulating gene expression involved in the pathogenesis of a disease. Also included are compounds useful as building blocks of said antisense oligonucleotides and methods of preparing said antisense oligonucleotides and building block compounds including NPN linkages.
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