Crystalline forms of afatinib monomaleate, preparation methods and pharmaceutical compositions thereof
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United States of America Patent
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Jul 18, 2017
Grant Date -
Jul 21, 2016
app pub date -
Jan 14, 2016
filing date -
Jan 15, 2015
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Abstract
The present invention relates to the novel solid forms of Afatinib monomaleate and preparation methods thereof; the solid forms of Afatinib monomaleate of the present invention have many improved properties as compared to the known crystalline form of Afatinib salt; and the present invention also relates to pharmaceutical compositions containing the novel solid forms of Afatinib monomaleate as well as the uses thereof for treating terminal non-small cell lung cancer (NSCLS) and HER2 positive advanced breast cancer.
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