Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
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United States of America Patent
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Jul 18, 2017
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Mar 3, 2016
app pub date -
Aug 28, 2015
filing date -
Aug 29, 2014
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Abstract
The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
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