Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain
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United States of America Patent
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Jul 18, 2017
Grant Date -
Apr 28, 2016
app pub date -
Jun 5, 2014
filing date -
Jun 5, 2013
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Abstract
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
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