Amperometric sensors and devices for measuring concentration of S-nitrosothiols based on photo-induced decomposition of S-nitrosothiols
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United States of America Patent
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Jul 11, 2017
Grant Date -
Jan 16, 2014
app pub date -
Apr 14, 2011
filing date -
Mar 30, 2011
priority date (Note) -
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Abstract
Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.
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