Hydrophobically modified antisense oligonucleotides comprising a ketal group
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United States of America Patent
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Jul 11, 2017
Grant Date -
Apr 21, 2016
app pub date -
Jun 5, 2014
filing date -
Jun 5, 2013
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Abstract
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
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