Tau imaging probe
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United States of America Patent
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Jul 11, 2017
Grant Date -
Sep 22, 2016
app pub date -
May 31, 2016
filing date -
Oct 29, 2010
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Abstract
An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity.
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